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The long-term effects on growth hormone secretion are of specific interest, as sustained rise of IGF-1 levels (whether from endogenous or exogenous sources) can suppress growth hormone release through negative feedback at the hypothalamic and pituitary levels

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OPINION: Childhood obesity gets a prescriptionand the food sector a warning Fifty-eight per cent of people taking or considering taking GLP-1 drugs said weight loss was their main driver, while 42% said diabetes was their primary reason

[1] [2] In the UK, according to their Summary of Product Characteristics (SmPCs), these medications are licensed for adults with a body mass index (BMI) of 30 kg/m or above, or 27 kg/m or above in the presence of weight-related comorbidities such as type 2 diabetes, hypertension, or obstructive sleep apnoea

This mechanistic evidence complements the epidemiological findings linking magnesium status to muscle outcomes